A 2022 study on lab-grown human skin cells examined the anti-inflammatory and anti-acne actions of Witch Hazel. The affected skin cells were exposed to glycolic extract derived from Witch Hazel bark. No antibacterial or antibiofilm activities were recorded, but researchers did observe anti-inflammatory properties due to the plant’s antioxidant activity. They concluded that more study should be done on Witch Hazel and inflammatory skin conditions.
Another study from 2022 examined Witch Hazel bark extract’s impact on inflammation caused by atopic dermatitis/eczema. Affected human keratinocytes were exposed to two types of Witch Hazel extracts. Both extracts showed actions that blocked the inflammatory and allergy responses. The researchers explain this study was the first to show the potential for Witch Hazel to treat atopic dermatitis symptoms, like itching and skin barrier issues.
Yet another ex vivo study published in 2021 examined Witch Hazel as skin protection from air pollution. The researchers exposed human keratinocytes to particulate matter and then to a solution containing the stems and leaves of the plant. The researchers concluded that Witch Hazel may offer “significant” protection from inflammation caused by particulate matter. It may also restore the skin barrier after damage.
A 2018 non-interventional trial and stability study examined using Witch Hazel extract to treat hemorrhoids. A total of 20 people were treated with suppositories and evaluated at one, two and eight days. On average, participants saw resolution of symptoms — bleeding, burning, itching and edema — within a week with no negative side effects.
Researchers have also studied Witch Hazel for topical treatment of hemorrhoids and varicose veins. In a review of treatment options, the ingredient is touted for its astringent and anti-inflammatory properties as well as its ability to stop bleeding. Additionally, in vivo studies show that Witch Hazel inhibits the enzymes alpha-glucosidase and human leukocyte elastase that lead to a breakdown in connective tissue.
A 2002 comparative study examined Witch Hazel and its effect on redness from UV exposure. A total of 40 volunteers tried one of three lotions, each containing 10% of Witch Hazel distillates with a different vehicle (dimethindene maleate gel, hydrocortisone cream and hydrocortisone lotion). They applied the lotions throughout a 48-hour period. All three formulas reduced redness and inflammation.
